Data di Pubblicazione:
2009
Citazione:
Structure revision of the Lantibiotic 97518 / S. I. Maffioli, D. Potenza, F. Vasile, M. De Matteo, M. Sosio, B. Marsiglia, V. Rizzo, C. Scolastico, S. Donadio. - In: JOURNAL OF NATURAL PRODUCTS. - ISSN 0163-3864. - 72:4(2009), pp. 605-607.
Abstract:
The lantibiotic 97518, produced by a Planomonospora sp., was reported as a 2194 Da polypeptide comprising 24 amino
acid residues with five thioether bridges. It was assigned to the mersacidin subgroup of type B lantibiotics by Castiglione
et al. (Biochemistry 2007, 46, 5884-5897) and named planosporicin. New analytical, chemical, and genetic data and
reinterpretation of the published NMR chemical shifts enable structure revision of 97518. The resulting revision of the
97518 structure involves both a shift of two amino acids and a reorganization of two thioether bridges. With this revision,
the lantibiotic 97518 becomes a clear member of the nisin subgroup of compounds.
acid residues with five thioether bridges. It was assigned to the mersacidin subgroup of type B lantibiotics by Castiglione
et al. (Biochemistry 2007, 46, 5884-5897) and named planosporicin. New analytical, chemical, and genetic data and
reinterpretation of the published NMR chemical shifts enable structure revision of 97518. The resulting revision of the
97518 structure involves both a shift of two amino acids and a reorganization of two thioether bridges. With this revision,
the lantibiotic 97518 becomes a clear member of the nisin subgroup of compounds.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
NMR, Lantibiotics
Elenco autori:
S. I. Maffioli, D. Potenza, F. Vasile, M. De Matteo, M. Sosio, B. Marsiglia, V. Rizzo, C. Scolastico, S. Donadio
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