Exposure to urban nanoparticles at low PM1 concentrations as a source of oxidative stress and inflammation
Articolo
Data di Pubblicazione:
2023
Citazione:
Exposure to urban nanoparticles at low PM1 concentrations as a source of oxidative stress and inflammation / F. Costabile, M. Gualtieri, M. Rinaldi, S. Canepari, R. Vecchi, L. Massimi, G. Di Iulio, M. Paglione, L. Di Liberto, E. Corsini, M.C. Facchini, S. Decesari. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 13:1(2023), pp. 18616.1-18616.18. [10.1038/s41598-023-45230-z]
Abstract:
Exposures to fine particulate matter (PM1 ) have been associated with health impacts, but the
understanding of the PM1 concentration-response (PM1-CR) relationships, especially at low PM1 ,
remains incomplete. Here, we present novel data using a methodology to mimic lung exposure to
ambient air (2< PM1 < 60 μg m−3), with minimized sampling artifacts for nanoparticles. A reference
model (Air Liquid Interface cultures of human bronchial epithelial cells, BEAS-2B) was used for
aerosol exposure. Non-linearities observed in PM1-CR curves are interpreted as a result of the
interplay between the aerosol total oxidative potential (OPt ) and its distribution across particle size
(dp ). A d p-dependent condensation sink (CS) is assessed together with the distribution with d p of
reactive species . Urban ambient aerosol high in OPt , as indicated by the DTT assay, with (possibly
copper-containing) nanoparticles, shows higher pro-inflammatory and oxidative responses, this
occurring at lower PM1 concentrations (< 5 μg m−3). Among the implications of this work, there are
recommendations for global efforts to go toward the refinement of actual air quality standards with
metrics considering the distribution of OPt with d p also at relatively low PM1.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
F. Costabile, M. Gualtieri, M. Rinaldi, S. Canepari, R. Vecchi, L. Massimi, G. Di Iulio, M. Paglione, L. Di Liberto, E. Corsini, M.C. Facchini, S. Decesari
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