Data di Pubblicazione:
2020
Citazione:
Designing Chimeric Molecules for Drug Discovery by Leveraging Chemical Biology / C. Borsari, D.J. Trader, A. Tait, M.P. Costi. - In: JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0022-2623. - 63:5(2020 Mar 12), pp. 1908-1928. [10.1021/acs.jmedchem.9b01456]
Abstract:
After the first seed concept introduced in the 18th century, different disciplines have attributed different names to dual-functional molecules depending on their application, including bioconjugates, bifunctional compounds, multitargeting molecules, chimeras, hybrids, engineered compounds. However, these engineered constructs share a general structure: a first component that targets a specific cell and a second component that exerts the pharmacological activity. A stable or cleavable linker connects the two modules of a chimera. Herein, we discuss the recent advances in the rapidly expanding field of chimeric molecules leveraging chemical biology concepts. This Perspective is focused on bifunctional compounds in which one component is a lead compound or a drug. In detail, we discuss chemical features of chimeric molecules and their use for targeted delivery and for target engagement studies.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
C. Borsari, D.J. Trader, A. Tait, M.P. Costi
Link alla scheda completa: