Tetraphenylethylene-Based Photoluminescent Self-Assembled Nanoparticles: Preparation and Biological Evaluation
Articolo
Data di Pubblicazione:
2023
Citazione:
Tetraphenylethylene-Based Photoluminescent Self-Assembled Nanoparticles: Preparation and Biological Evaluation / E. Colombo, E.M. Aydın, İ.S. Canıtez, L. Polito, M. Penconi, A. Bossi, E. Impresari, D. Passarella, S. Dallavalle, C.M. Athanassopoulos, S. Pellegrino, I.D. Şahin, M.S. Christodoulou. - In: ACS MEDICINAL CHEMISTRY LETTERS. - ISSN 1948-5875. - 14:10(2023 Oct 12), pp. 1472-1477. [10.1021/acsmedchemlett.3c00396]
Abstract:
The conjugation of tetraphenylethylene (TPE) with podophyllotoxin, N-desacetyl-thiocolchicine, and cabazitaxel through a sebacic acid linker led to the formation of fluorescent nanoparticles. Dynamic light scattering (DLS) and photoluminescence spectroscopy were used for the identification and characterization of the fluorescent nanoparticles. The biological evaluation was determined in three human ovarian (KURAMOCHI, OVCAR3, OVSAHO) and three human breast (MCF7, SKBR 3, and MDA-MB231) cancer cell lines. In the case of cabazitaxel, the nanoparticles maintained the activity of the parent drug, at the low nanomolar range, while exhibiting high blue fluorescence. The internalization of the fluorescent NPs into cells was detected using immunofluorescence assay.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Tetraphenylethylene; self-assemblednanoparticles; cancer cell lines; podophyllotoxin; N-desacetylthiocolchicine; cabazitaxel; aggregation-induced emission;
Elenco autori:
E. Colombo, E.M. Aydın, İ.S. Canıtez, L. Polito, M. Penconi, A. Bossi, E. Impresari, D. Passarella, S. Dallavalle, C.M. Athanassopoulos, S. Pellegrino, I.D. Şahin, M.S. Christodoulou
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