Which clinical factors and biochemical parameters are associated with late-life major depression?
Articolo
Data di Pubblicazione:
2023
Citazione:
Which clinical factors and biochemical parameters are associated with late-life major depression? / M. Buoli, F. Legnani, G. Nosari, A. Pan, V. Ciappolino, C. Esposito, A. Ceresa, M. Di Paolo, T. Surace, A. Auxilia, M. Capellazzi, I. Tagliabue, L. Cirella, F. Zanelli Quarantini, A. Dakanalis, M. Clerici, E. Capuzzi, A. Caldiroli. - In: INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE. - ISSN 1471-1788. - (2023 Sep), pp. 1-8. [Epub ahead of print] [10.1080/13651501.2023.2260426]
Abstract:
Introduction: Late-life major depression (MD) is a frequent and high-cost psychiatric disorder. Our purpose was to detect clinical and biological factors possibly associated with this condition to better prevent and treat it.
Methods: We recruited 343 patients, consecutively admitted for a Major Depressive Episode to the inpatient clinic of Policlinico of Milan and ASST Monza, Italy. A large set of clinical and biochemical variables was collected from clinical charts. Univariate analyses were performed both dividing the sample into two groups (age < or ≥65) and considering age as a continuous quantitative variable. Regression analyses were then performed considering as independent variables only those statistically significant at univariate analyses.
Results: Patients aged ≥ 65 resulted in having longer duration of illness, shorter duration of last antidepressant therapy, higher number of antidepressants assumed in the past, higher frequency of treatment-resistant depression, higher frequency of overweight/obesity and diabetes. As for biochemical parameters, patients ≥ 65 showed lower total plasmatic proteins and albumin, higher uric acid and creatinine.
Conclusions: These preliminary results suggest less effectiveness of antidepressants, more susceptibility to metabolic disorders and poor nutritional status in patients with late-life depression; such aspects may consequently be taken into consideration for a proper therapeutic approach.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
age; biochemical markers; clinical; features; late life; Unipolar depression
Elenco autori:
M. Buoli, F. Legnani, G. Nosari, A. Pan, V. Ciappolino, C. Esposito, A. Ceresa, M. Di Paolo, T. Surace, A. Auxilia, M. Capellazzi, I. Tagliabue, L. Cirella, F. Zanelli Quarantini, A. Dakanalis, M. Clerici, E. Capuzzi, A. Caldiroli
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