Data di Pubblicazione:
2021
Citazione:
NETosis in Wound Healing: When Enough Is Enough / M. Sabbatini, V. Magnelli, F. Renò. - In: CELLS. - ISSN 2073-4409. - 10:3(2021), pp. 494.1-494.13. [10.3390/cells10030494]
Abstract:
The neutrophils extracellular traps (NETs) are a meshwork of chromatin, histonic and non-histonic proteins, and microbicidal agents spread outside the cell by a series of nuclear and cytoplasmic events, collectively called NETosis. NETosis, initially only considered a defensive/apoptotic mechanism, is now considered an extreme defensive solution, which in particular situations induces strong negative effects on tissue physiology, causing or exacerbating pathologies as recently shown in NETs-mediated organ damage in COVID-19 patients. The positive effects of NETs on wound healing have been linked to their antimicrobial activity, while the negative effects appear to be more common in a plethora of pathological conditions (such as diabetes) and linked to a NETosis upregulation. Recent evidence suggests there are other positive physiological NETs effects on wound healing that are worthy of a broader research effort.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
inflammation; innate immunity; netosis; wound healing
Elenco autori:
M. Sabbatini, V. Magnelli, F. Renò
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