Administration of ethanol during brain growth spurt causes dose-dependent microencephaly and inhibition of muscarinic receptor-stimulated phosphoinositide metabolism in the rat
Articolo
Data di Pubblicazione:
1994
Citazione:
Administration of ethanol during brain growth spurt causes dose-dependent microencephaly and inhibition of muscarinic receptor-stimulated phosphoinositide metabolism in the rat / F. Reno', X.X. Tan, W. Balduini, L.G. Costa. - In: RESEARCH COMMUNICATIONS IN ALCOHOL AND SUBSTANCES ABUSE. - ISSN 1080-8388. - 15:3-4(1994), pp. 141-150.
Abstract:
Different dose levels of ethanol (2,3,4,5 g/kg) were administered to rat pups between postnatal days 4 and 10. Ethanol caused a dose-dependent decrease in brain weight (measured on postnatal day 12) and inhibition of carbachol-stimulated phosphoinositide metabolism (measured in cerebral cortex slices on postnatal day 7). The 2 g/kg dose, which gave blood alcohol levels of 128 mg/dl, was a no-effect-level for both endpoints. Ethanol administration did not alter the relative distribution of phosphoinositides in the cerebral cortex from 7 day-old rats. These results show a dose-dependent correlation between ethanol-induced microencephaly and inhibition of muscarinic receptor-stimulated phosphoinositide metabolism and add support to the hypothesis that this second messenger system may be involved in the developmental neurotoxicity of ethanol.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
F. Reno', X.X. Tan, W. Balduini, L.G. Costa
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