Nicotine stimulation increases proliferation and matrix metalloproteinases-2 and -28 expression in human dental pulp cells
Articolo
Data di Pubblicazione:
2015
Citazione:
Nicotine stimulation increases proliferation and matrix metalloproteinases-2 and -28 expression in human dental pulp cells / M. Rizzi, M. Migliario, V. Rocchetti, F. Reno'. - In: LIFE SCIENCES. - ISSN 0024-3205. - 135:(2015), pp. 49-54. [10.1016/j.lfs.2015.04.027]
Abstract:
Dental pulp is the specialized tissue responsible for maintaining tooth viability. When tooth mineralized matrix is damaged, pulp is exposed to a plethora of environmental stimuli. In particular, in smokers, pulp become exposed to very high concentrations of nicotine. The aim of this study was to investigate the effect of direct nicotine stimulation on human dental pulp cell proliferation. Moreover, as it is known that nicotine could upregulate the expression of matrix metalloproteinases (MMPs), enzymes involved in pulpal inflammation, the effects of nicotine stimulation on MMP-2 and MMP-28 gene expression have also been investigated.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Dental pulp; Hexamethonium chloride; MAPK; MMPs; Nicotine
Elenco autori:
M. Rizzi, M. Migliario, V. Rocchetti, F. Reno'
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