Vitamin E triggers Poly(2-hydroxyethyl methacrylate) (PHEMA) embolic potential: a proposed application for endovascular surgery
Articolo
Data di Pubblicazione:
2011
Citazione:
Vitamin E triggers Poly(2-hydroxyethyl methacrylate) (PHEMA) embolic potential: a proposed application for endovascular surgery / F. Reno', V. Traina, S. Gatti, M. Cannas. - In: JOURNAL OF BIOMATERIALS SCIENCE POLYMER EDITION. - ISSN 0920-5063. - 22:4-6(2011), pp. 641-650. [10.1163/092050610X489303]
Abstract:
Poly(2-hydroxyethyl methacrylate) (PHEMA) is a biocompatible polymer used as embolizing agent for endovascular surgery. Blending of PHEMA with a hydrophobic and anti-oxidant agent, Vitamin E (Vit.E, 0.1-10%, w/v), modified PHEMA's haemocombatibility, evaluated measuring wettability, plasma protein adsorption along with whole blood coagulation time. The presence of Vit.E increases PHEMA's hydrophobicity and plasma protein adsorption (in particular albumin and Immunoglobulin G), while it also accelerates blood clot formation. These effects are developed due to a combination of issues such as surface hydrophobicity and plasma protein adsorption induced by the presence of Vit.E, suggesting that Vit.E blending could improve the use of PHEMA as embolizing agent.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
albumin; blood clot; endovascular surgery; immunoglobulin g; Phema; vitamin e; wettability
Elenco autori:
F. Reno', V. Traina, S. Gatti, M. Cannas
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