Data di Pubblicazione:
1999
Citazione:
Mimosine induces apoptosis in the HL60 human tumor cell line / F. Reno', A. Tontini, S. Burattini, S. Papa, E. Falcieri, G. Tarzia. - In: APOPTOSIS. - ISSN 1360-8185. - 4:6(1999), pp. 469-477. [10.1023/A:1009608628076]
Abstract:
Mimosine, a plant amino acid not found in proteins, has been widely used as a synchronizing agent, blocking the progression of cell cycle on the G1/S phase border. The mechanism by which this block is achieved is still unclear. We report that in HL60 cells the synchronization is related to an increase in apoptosis. Another human tumor cell line, K562, is insensitive to both phenomena thereby demonstrating that apoptosis observed in HL60 is line- specific. We hypothesize that the mimosine-induced apoptosis and alteration of the cell cycle is due to the inhibition of hypusine generation.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Apoptosis; cell cycle synchronization; HL60; hypusine; K562; mimosine
Elenco autori:
F. Reno', A. Tontini, S. Burattini, S. Papa, E. Falcieri, G. Tarzia
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