Data di Pubblicazione:
2013
Citazione:
Epiregulin induces human SK-N-BE cell differentiation through ERK1/2 signaling pathway / M. Rizzi, P. Pittarella, M. Sabbatini, F. Reno'. - In: GROWTH FACTORS. - ISSN 0897-7194. - 31:3(2013), pp. 90-97.
Abstract:
Epidermal growth factor (EGF) and other EGF-related growth factors, such as transforming growth factor-α, are able to stimulate neuroblastoma (NB) cell proliferation. Epiregulin (Epi) is a growth factor belonging to the EGF family known to be more potent than EGF in mediating mitogenic signals. In this study, we tested the ability of Epi to stimulate a human NB cell line (SK-N-BE) proliferation. Surprisingly, Epi (50-1000ng/ml) induced a reduction in SK-N-BE proliferation along with a morphological differentiation, associated with an increase in MMP-9 expression. Moreover, Epi-induced differentiation was inhibited by ERK1/2 phosphorilation inhibition. In conclusion, Epi could represent a novel and useful tool to oppose NB cell proliferation.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
differentiation; ERK1/2; MMPs; neuroblastoma; SK-N-BE cell line
Elenco autori:
M. Rizzi, P. Pittarella, M. Sabbatini, F. Reno'
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