Interference with complement regulatory molecules as a possible therapeutic strategy in HIV infection
Articolo
Data di Pubblicazione:
2000
Citazione:
Interference with complement regulatory molecules as a possible therapeutic strategy in HIV infection / C. Pinter, S. Beltrami, H. Stoiber, D. R. M. Negri, F. Titti, A. Clivio. - In: EXPERT OPINION ON INVESTIGATIONAL DRUGS. - ISSN 1354-3784. - 9:2(2000), pp. 199-205.
Abstract:
Drugs which inhibit different stages of the HIV infection process, such as cell entry through CD4 and chemokine receptors, production of double stranded DNA from the HIV genome and maturation of newly produced viruses, are now proposed for AIDS therapy. None of these treatments, however, solve the problem of complete HIV eradication and the frequent appearance of mutants displaying drug resistance. We have recently detailed a strategy describing how HIV protects itself from the human complement and propose that interference of this resistance could be a possible target for therapy.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
AIDS therapy; Complement; HIV; Vaccine
Elenco autori:
C. Pinter, S. Beltrami, H. Stoiber, D. R. M. Negri, F. Titti, A. Clivio
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