Data di Pubblicazione:
2007
Citazione:
PSA-NCAM in the developing and mature thalamus / S. Mazzetti, B. Ortino, F. Inverardi, C. Frassoni, A. Amadeo. - In: BRAIN RESEARCH BULLETIN. - ISSN 0361-9230. - 71:6(2007), pp. 578-586.
Abstract:
The polysialylated form of the neural cell adhesion molecule (PSA-NCAM) is involved in several morphogenetic processes of the central nervous
system. In the present study the expression of PSA-NCAM has been investigated in the rat thalamus during embryonic and postnatal development
using light and electron microscopic immunocytochemical techniques. At all the examined ages, PSA-NCAM staining in the thalamus was mainly
observed along neuronal plasmatic membranes and absent in astrocytes identified by labelling with cytoskeletal (vimentin and glial fibrillary
acidic protein) and membrane (GABA transporter-3) markers. At embryonic day 14 the immunoreactivity was restricted to the dorsal thalamic
mantle and to the region of reticular thalamic migration and subsequently it extended throughout the whole thalamic primordium. PSA-NCAM
labelling remained intense and homogeneously distributed along perinatal period, but from P4 it began to decrease selectively, persisting throughout
adulthood only in the reticular nucleus, ventral lateral geniculate nucleus and midline and intralaminar nuclei. The expression of this adhesion
molecule differed in areas characterized by the presence of neurons containing distinct calcium binding proteins, as PSA-NCAM labelling was
intense around calretinin-positive neurons, whereas it decreased in some calbindin-immunoreactive regions.
These findings show evidence of a selective neuronal expression of PSA-NCAM in developing thalamus, supporting its suggested role in cell
migration and synaptogenesis as it occurs in the cerebral cortex. In adulthood PSA-NCAM could instead be a marker of thalamic nuclei that retain
a potential for synaptic plasticity.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Adhesion molecule; Axonal growth; Neuronal migration; Polysialic acid; Sensory systems; Synaptic plasticity
Elenco autori:
S. Mazzetti, B. Ortino, F. Inverardi, C. Frassoni, A. Amadeo
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