Data di Pubblicazione:
2010
Citazione:
Hepatitis C virus infection and lichen
planus: a systematic review with meta-analysis / G. Lodi, R. Pellicano, M. Carrozzo. - In: ORAL DISEASES. - ISSN 1354-523X. - 16:7(2010 Oct), pp. 601-612.
Abstract:
Oral Diseases (2010) doi: 10.1111/j.1601-0825.2010.01670.x Objective: Hepatitis C
virus (HCV) is one of the major causes of chronic liver disease worldwide but its
morbidity is also due to a variety of extra-hepatic manifestations including
mixed cryoglubulinemia, non-Hodgkin lymphoma, diabetes, porphyria cutanea tarda
and lichen planus. The aims of this study were to conduct a systematic review and
a meta-analysis on the prevalence of HCV in lichen planus patients and on the
prevalence of lichen planus in chronic HCV infection. Materials and Method:
Bibliographic searches were conducted in several electronic databases. Pooled
data were analysed by calculating odds ratios, using a random effects model.
Results and Conclusions: Thirty-three studies comparing the seroprevalence of HCV
in lichen planus patients and six reporting the prevalence of lichen planus in
patients with HCV infection were included in the meta-analysis. The summary
estimate showed that LP patients have significantly higher risk (odds ratio 4.85;
95% confidence interval 3.58-6.56) than controls of being HCV seropositive. A
similar odds ratio of having lichen planus was found among HCV patients (4.47;
95% confidence interval 1.84-10.86). Sub-analyses indicated that variability of
HCV/lichen planus association seemed only partially depending on geographic
effect.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
hepatitis C virus; lichen planus; meta-analysis; oral lichen planus
Elenco autori:
G. Lodi, R. Pellicano, M. Carrozzo
Link alla scheda completa: