Data di Pubblicazione:
2007
Citazione:
Fluconazole induces teratogenic effects in the tunicate Phallusia mammillata / S. Groppelli, G. Zega, M. Biggiogero, F. De Bernardi, C. Sotgia, R. Pennati. - In: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY. - ISSN 1382-6689. - 23:3(2007), pp. 265-271.
Abstract:
Fluconazole (FLUCO) is an azole derivative used to treat fungal and yeast infections. Embryotoxicity tests on the ascidian Phallusia mammillata
were performed to evaluate the effects of this drug. FLUCO proved to have strong consequences on P. mammillata development. Incidence of
malformations and of lethality increased in a dose dependent way. Probit analysis showed that FLUCO had a high TI value (Teratogenic Index,
LC50/TC50), thus this substance could be classified as a teratogenic compound for ascidians. Larvae exposed to FLUCO showed a typical phenotype characterized by malformations restricted to the trunk region: the trunk appeared round in shape with flat palps, the sensory vesicle cavity was
absent or reduced and the anterior central nervous system failed to correctly differentiate. These anomalies resulted similar to those induced by
retinoic acid (RA) treatment. Thus, it could be hypothesized that FLUCO and RA may act with a similar pathogenic mechanism in ascidian larvae,
as it has been proposed for mammals.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
ascidian; embryotoxicity; chordate; antimycotic; azole; retinoic acid
Elenco autori:
S. Groppelli, G. Zega, M. Biggiogero, F. De Bernardi, C. Sotgia, R. Pennati
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