Prokineticin System Is a Pharmacological Target to Counteract Pain and Its Comorbid Mood Alterations in an Osteoarthritis Murine Model
Articolo
Data di Pubblicazione:
2023
Citazione:
Prokineticin System Is a Pharmacological Target to Counteract Pain and Its Comorbid Mood Alterations in an Osteoarthritis Murine Model / G. Galimberti, G. Amodeo, G. Magni, B. Riboldi, G. Balboni, V. Onnis, S. Ceruti, P. Sacerdote, S. Franchi. - In: CELLS. - ISSN 2073-4409. - 12:18(2023 Sep 12), pp. 2255.1-2255.24. [10.3390/cells12182255]
Abstract:
Osteoarthritis (OA) is the most prevalent joint disease associated with chronic pain. OA
pain is often accompanied by mood disorders. We addressed the role of the Prokineticin (PK) system
in pain and mood alterations in a mice OA model induced with monosodium iodoacetate (MIA). The
effect of a PK antagonist (PC1) was compared to that of diclofenac. C57BL/6J male mice injected with
MIA in the knee joint were characterized by allodynia, motor deficits, and fatigue. Twenty-eight days
after MIA, in the knee joint, we measured high mRNA of PK2 and its receptor PKR1, pro-inflammatory
cytokines, and MMP13. At the same time, in the sciatic nerve and spinal cord, we found increased
levels of PK2, PKR1, IL-1β, and IL-6. These changes were in the presence of high GFAP and CD11b
mRNA in the sciatic nerve and GFAP in the spinal cord. OA mice were also characterized by
anxiety, depression, and neuroinflammation in the prefrontal cortex and hippocampus. In both
stations, we found increased pro-inflammatory cytokines. In addition, PK upregulation and reactive
astrogliosis in the hippocampus and microglia reactivity in the prefrontal cortex were detected. PC1
reduced joint inflammation and neuroinflammation in PNS and CNS and counteracted OA pain and
emotional disturbances.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
prokineticins; osteoarthritis pain; neuroinflammation; anxiety; depression
Elenco autori:
G. Galimberti, G. Amodeo, G. Magni, B. Riboldi, G. Balboni, V. Onnis, S. Ceruti, P. Sacerdote, S. Franchi
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