Data di Pubblicazione:
2004
Citazione:
Antidepressants activate CaMKII in neuron cell
body by Thr286 phosphorylation / E. Tiraboschi, R. Giambelli, G. D'Urso, A. Galietta, A. Barbon, A. de Bartolomeis, M. Gennarelli, S. Barlati, G. Racagni, M. Popoli. - In: NEUROREPORT. - ISSN 0959-4965. - 15:15(2004), pp. 2393-2396.
Abstract:
CaM kinase II, a regulator of synaptic plasticity, is implicated in
pathophysiology and pharmacology of psychiatric disorders.
Chronic treatment with antidepressants desipramine and reboxetine
up-regulated CaM kinase II in neuronal cell bodies of hippocampus.
mRNA/protein expression for aCaM kinase II
was unchanged, whereas Thr286 phosphorylation was increased
in pyramidal/granular cell bodies, suggesting that increased
phosphorylation is responsible for kinase activation. Short-term
treatment of neuronal cultureswith reboxetine reduced kinase activation
in a concentration-dependentmanner.The short-terminhibitory
e¡ect of reboxetine suggests that kinase up-regulation during antidepressant drug treatment is an adaptive response compensating for initial functional down-regulation.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Antidepressant ; CaMkinase II ; Hippocampus ; Neuroplasticity ; Phosphorylation
Elenco autori:
E. Tiraboschi, R. Giambelli, G. D'Urso, A. Galietta, A. Barbon, A. de Bartolomeis, M. Gennarelli, S. Barlati, G. Racagni, M. Popoli
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