Blockade of stress-induced increase of glutamate release in the rat prefrontal/frontal cortex by agomelatine involves synergy between melatonergic and 5-HT2C receptor-dependent pathways
Articolo
Data di Pubblicazione:
2010
Citazione:
Blockade of stress-induced increase of glutamate release in the rat prefrontal/frontal cortex by agomelatine involves synergy between melatonergic and 5-HT2C receptor-dependent pathways / D. Tardito, M. Milanese, T. Bonifacino, L. Musazzi, A. Mallei, E. Mocaer, C. Gabriel, G. Racagni, M. Popoli, G. Bonanno. - In: BMC NEUROSCIENCE. - ISSN 1471-2202. - 11(2010), pp. 68.68.1-68.68.4. [10.1186/1471-2202-11-68]
Abstract:
Background. Agomelatine is a melatonergic receptor agonist and a 5HT2C receptor
antagonist that has shown ntidepressant efficacy. In order to analyze separately the effect
of the two receptorial components, rats were chronically treated with agomelatine, melatonin
(endogenous melatonergic agonist), or S32006 (5-HT2C antagonist), and then subjected to acute footshock-stress.
Results. Only chronic agomelatine, but not melatonin or S32006, completely prevented the stress-induced increase of glutamate release in the rat prefrontal/frontal cortex.
Conclusions. These results suggest a potential synergy between melatonergic and serotonergic pathways in the action of agomelatine.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
D. Tardito, M. Milanese, T. Bonifacino, L. Musazzi, A. Mallei, E. Mocaer, C. Gabriel, G. Racagni, M. Popoli, G. Bonanno
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