E-selectin A561C and G98T polymorphisms influence susceptibility and course of multiple sclerosis
Articolo
Data di Pubblicazione:
2005
Citazione:
E-selectin A561C and G98T polymorphisms influence susceptibility and course of multiple sclerosis / D. Galimberti, C. Fenoglio, R. Clerici, C. Comi, M. De Riz, M. Rottoli, L. Piccio, M. Ronzoni, E. Venturelli, F. Monaco, M. Poloni, N. Bresolin, E. Scarpini. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - 165:1-2(2005), pp. 201-205.
Abstract:
Three hundred seven patients with MS and 300 controls were genotyped for G98T and A561C SNPs in the E-selectin gene, and genetic data were correlated with the course of the disease. The frequency of the T/T genotype of the G98T SNP was significantly increased in RR-MS patients compared with controls, while was absent in PP-MS. The frequency of the A561C SNP was significantly decreased in SP-MS compared with benign RR-MS. The T/T genotype of the G98T SNP is likely to confer an increased risk to develop MS. The A561C polymorphism seems to act as protective factor towards the progression to SP-MS.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
D. Galimberti, C. Fenoglio, R. Clerici, C. Comi, M. De Riz, M. Rottoli, L. Piccio, M. Ronzoni, E. Venturelli, F. Monaco, M. Poloni, N. Bresolin, E. Scarpini
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