Data di Pubblicazione:
2023
Citazione:
Tryptophan-PNA gc Conjugates Self-Assemble to Form Fibers / A. Mosseri, M. Sancho-Albero, F. Mercurio, M. Leone, L. De Cola, A. Romanelli. - In: BIOCONJUGATE CHEMISTRY. - ISSN 1043-1802. - 34:8(2023 Jul 24), pp. 1429-1438. [10.1021/acs.bioconjchem.3c00200]
Abstract:
Peptide nucleic acids and their conjugates to peptidescan self-assembleand generate complex architectures. In this work, we explored theself-assembly of PNA dimers conjugated to the dipeptide WW. Our studiessuggest that the indole ring of tryptophan promotes aggregation ofthe conjugates. The onset of fluorescence is observed upon self-assembly.The structure of self-assembled WWgc is concentration-dependent, beingspherical at low concentrations and fibrous at high concentrations.As suggested by molecular modeling studies, fibers are stabilizedby stacking interactions between tryptophans and Watson-Crick hydrogenbonds between nucleobases.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Peptide Nucleic Acid, conjugate, peptides, fiber, self-assembly;
Elenco autori:
A. Mosseri, M. Sancho-Albero, F. Mercurio, M. Leone, L. De Cola, A. Romanelli
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