Immunohistochemical expression of the KIT protein (CD117) in normal and neoplastic canine testes
Articolo
Data di Pubblicazione:
2010
Citazione:
Immunohistochemical expression of the KIT protein (CD117) in normal and neoplastic canine testes / V. Grieco, B. Banco, C. Giudice, F. Mosca, M. Finazzi. - In: JOURNAL OF COMPARATIVE PATHOLOGY. - ISSN 0021-9975. - 142:2/3(2010), pp. 213-217. [10.1016/j.jcpa.2009.07.002]
Abstract:
The aim of the present study was to characterize the expression of the KIT protein (CD117) in normal and
neoplastic canine testes. Archival samples of normal testis (n 5), interstitial cell tumours (ICTs; n 10), Sertoli
cell tumours (SCTs; n 10) and seminomas (n 10) were selected. Seminomas were subclassified on the
basis of expression of placental alkaline phosphatase (PLAP) as classical seminoma (SE; PLAP positive;
n 5) or spermatocytic seminoma (SS; PLAP negative; n 5). In normal testes, KIT expression was observed
in Leydig cells and in spermatogonia. All ICTs expressed KIT, but no SCT was positively labelled. Seven of 10
seminomas expressed KIT and these tumours were reclassified on this basis as SS (KIT negative) or SE (KIT
positive). These findings are consistent with observations of SE in man where many of the neoplastic cells reach
the stage of spermatogonia where PLAP expression is lost and that of KIT is maintained. It would therefore
appear that immunolabelling for KIT expression is a more appropriate means of distinguishing between canine
SE and SS.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Dog; Immunohistochemistry; KIT protein; Testis
Elenco autori:
V. Grieco, B. Banco, C. Giudice, F. Mosca, M. Finazzi
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