Data di Pubblicazione:
2023
Citazione:
Therapeutic Applications of Botulinum Neurotoxins in Veterinary Medicine / L. Turin, M. Michela Piccione, F. Crosa, D. Paola, F. Joel, L. Zarucco. - In: VETERINARY SCIENCES. - ISSN 2306-7381. - 10:7(2023), pp. 460.1-460.16. [10.3390/vetsci10070460]
Abstract:
Botulinum neurotoxins (BoNTs) are emerging as multipurpose therapeutic compounds
for the treatment of several different syndromes involving peripheral and central nervous systems,
and muscular and musculoskeletal disorders both in human and veterinary medicine. Therefore, the
study of BoNTs is rapidly developing and identifying newly produced BoNT variants. Efforts should
be made to clarify the biological and pharmacological characteristics of these novel BoNTs as well as
the natural ones. The high potential of BoNTs as a therapeutic compound for medical syndromes
lies in its ability to reach a specific cell type while bypassing other cells, thus having mild or no side
effects. In this paper the recent developments in BoNTs are reviewed with the aim of analyzing
the current knowledge on BoNTs’ biological mechanisms of action, immunogenicity, formulations,
and therapeutic applications in the veterinary field, highlighting advantages and drawbacks and
identifying the gaps to be filled in order to address research priorities.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Clostridium botulinum; botulism; neurotoxin; BoNT; therapeutic; antibodies; horse; dog; cat; farm animals
Elenco autori:
L. Turin, M. Michela Piccione, F. Crosa, D. Paola, F. Joel, L. Zarucco
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