The in vitro effects of cigarette smoke on fatty acid metabolism are partially counteracted by simvastatin
Articolo
Data di Pubblicazione:
2009
Citazione:
The in vitro effects of cigarette smoke on fatty acid metabolism are partially counteracted by simvastatin / P. Risé, S. Ghezzi, C. Manzoni, C. Colombo, C. Galli. - In: PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS. - ISSN 0952-3278. - 80:1(2009), pp. 71-75. [10.1016/j.plefa.2008.11.005]
Abstract:
Background: Statins enhance the synthesis of long-chain polyunsaturated fatty acids (LC-PUFAs) from
their precursors both in vitro and in vivo. In particular, an increased conversion of linoleic acid (LA) and
of alpha-linolenic acid to their derivatives is observed in cultured cells. On the contrary, cigarette smoke
(CS) negatively and dose-dependently affects the LC-PUFA production.
Aim: To evaluate the effects of CS alone or with simvastatin, on [1-14C] LA metabolism in THP-1 cells.
Results: CS inhibits LA conversion; after co-incubation, simvastatin nullifies the effects of CS,
maintaining LA conversion comparable to controls. However, at the highest CS concentration,
simvastatin is unable to counteract the effects of CS. Changes of LA conversion reflect the modulation
of desaturase activities by simvastatin and CS.
Conclusion: CS decreases PUFA conversion and its effects are modulated by the opposite effect of statins.
It can be speculated that statin treatments in smoking patients may provide some beneficial effects on PUFA metabolism in addition to lowering cholesterol levels
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Cigarette smoke; Cultured cells; Fatty acid desaturases; Fatty acid metabolism; Simvastatin
Elenco autori:
P. Risé, S. Ghezzi, C. Manzoni, C. Colombo, C. Galli
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