Randomized noninferiority field trial evaluating a postmilking teat dip for the prevention of naturally occurring intramammary infections
Articolo
Data di Pubblicazione:
2023
Citazione:
Randomized noninferiority field trial evaluating a postmilking teat dip for the prevention of naturally occurring intramammary infections / V. Krömker, N. Rota, C. Locatelli, C. Gusmara, A. Marinoni, D. Molteni, A. Schmenger, R.E. Erk, P. Moroni. - In: JOURNAL OF DAIRY SCIENCE. - ISSN 0022-0302. - (2023), pp. 1-11. [Epub ahead of print] [10.3168/jds.2022-22732]
Abstract:
The aim of this study was to perform a positive-
controlled field study under natural exposure condi-
tions to test the efficacy of a newly developed chlorine
dioxide-based postmilking teat disinfectant (experi-
mental product, EX) for noninferiority compared with
an already established chlorine dioxide-based teat dis-
infectant (positive control product, PC). After blocking
by parity, approximately 200 Holstein cows in early to
mid-lactation stages from a dairy farm near Padua,
Italy, were randomly assigned to one of 2 groups. Over
a 13-wk period between September and December
2021, the teats of cows were dipped with the EX or
the PC after each milking. Milk samples were collected
from individual quarters of enrolled cows for 13 wk to
determine infection status. Teat condition was assessed
at wk 1, 5, and 9. Mixed logistic regression was used to
analyze the effect of treatment on the incidence of new
intramammary infections. For the noninferiority analy-
sis, the upper limit of the 95% confidence interval for
the difference in new intramammary infection (NIMI)
rate between the 2 treatments (EX − PC) had to be to
the left of the critical value d (0.035) to conclude that
EX was noninferior to PC in terms of the risk of NIMI.
The results showed that the incidence of new infections
in the quarters treated with EX (3.1%) was not differ-
ent from that in the udder quarters treated with PC
(2.6%). No overall difference was found between the
treatments in terms of teat condition. As the upper
limit of the 95% confidence interval of the NIMI rate
difference was smaller than the predefined noninferior-
ity limit, we concluded that the EX was noninferior
compared with the PC.
Key words: teat disinfectant, chlorine dioxide,
intramammary infection, noninferiority limit, we concluded that the EX was noninferior
compared with the PC.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
teat disinfectant; chlorine dioxide; intramammary infection; noninferiority
Elenco autori:
V. Krömker, N. Rota, C. Locatelli, C. Gusmara, A. Marinoni, D. Molteni, A. Schmenger, R.E. Erk, P. Moroni
Link alla scheda completa: