Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice
Articolo
Data di Pubblicazione:
2010
Citazione:
Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice / A. Tocchetti, C.B. Soppo, F. Zani, F. Bianchi, M.C. Gagliani, B. Pozzi, J. Rozman, R. Elvert, N. Ehrhardt, B. Rathkolb, C. Moerth, M. Horsch, H. Fuchs, V. Gailus-Durner, J. Beckers, M. Klingenspor, E. Wolf, M. Hrabé de Angelis, E. Scanziani, C. Tacchetti, G. Scita, P.P. Di Fiore, N. Offenhäuser. - In: PLOS ONE. - ISSN 1932-6203. - 5:3(2010 Mar 02), pp. e9468.e9468.1-e9468.e9468.14. [10.1371/journal.pone.0009468]
Abstract:
Background: In a variety of organisms, including mammals, caloric restriction improves metabolic status and lowers the incidence of chronic-degenerative diseases, ultimately leading to increased lifespan. Methodology/Principal Findings: Here we show that knockout mice for Eps8, a regulator of actin dynamics, display reduced body weight, partial resistance to age- or diet-induced obesity, and overall improved metabolic status. Alteration in the liver gene expression profile, in behavior and metabolism point to a calorie restriction-like phenotype in Eps8 knockout mice. Additionally, and consistent with a calorie restricted metabolism, Eps8 knockout mice show increased lifespan. The metabolic alterations in Eps8 knockout mice correlated with a significant reduction in intestinal fat absorption presumably caused by a 25% reduction in intestinal microvilli length. Conclusions/Significance: Our findings implicate actin dynamics as a novel variable in the determination of longevity. Additionally, our observations suggest that subtle differences in energy balance can, over time, significantly affect bodyweight and metabolic status in mice.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
A. Tocchetti, C.B. Soppo, F. Zani, F. Bianchi, M.C. Gagliani, B. Pozzi, J. Rozman, R. Elvert, N. Ehrhardt, B. Rathkolb, C. Moerth, M. Horsch, H. Fuchs, V. Gailus Durner, J. Beckers, M. Klingenspor, E. Wolf, M. Hrabé de Angelis, E. Scanziani, C. Tacchetti, G. Scita, P.P. Di Fiore, N. Offenhäuser
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