Data di Pubblicazione:
1997
Citazione:
A role for the Ras signalling pathway in synaptic transmission and long-term memory / R. Brambilla, N. Gnesutta, L. Minichiello, G. White, A.J. Roylance, C.E. Herron, M. Ramsey, D.P. Wolfer, V. Cestari, C. Rossi Arnaud, S.G.N. Grant, P.F. Chapman, H.P. Lipp, E. Sturani, R. Klein. - In: NATURE. - ISSN 0028-0836. - 390:6657(1997), pp. 281-286.
Abstract:
Members of the Ras subfamily of small guanine-nucleotide-binding proteins are essential for controlling normal and malignant cell proliferation as well as cell differentiation. The neuronal-specific guanine-nucleotide-exchange factor, Ras-GRF/CDC25Mm, induces Ras signalling in response to Ca2+ influx and activation of G-protein-coupled receptors in vitro, suggesting that it plays a role in neurotransmission and plasticity in vivo. Here we report that mice lacking Ras-GRF are impaired in the process of memory consolidation, as revealed by emotional conditioning tasks that require the function of the amygdala; learning and short-term memory are intact. Electrophysiological measurements in the basolateral amygdala reveal that long-term plasticity is abnormal in mutant mice. In contrast, Ras-GRF mutants do not reveal major deficits in spatial learning tasks such as the Morris water maze, a test that requires hippocampal function. Consistent with apparently normal hippocampal functions, Ras-GRF mutants show normal NMDA (N-methyl-D-aspartate) receptor-dependent long-term potentiation in this structure. These results implicate Ras-GRF signalling via the Ras/MAP kinase pathway in synaptic events leading to formation of long-term memories.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Muscarinic receptors; exchange factor; protein; potentiation; activation; amygdala; mice; identification; plasticity; induction
Elenco autori:
R. Brambilla, N. Gnesutta, L. Minichiello, G. White, A.J. Roylance, C.E. Herron, M. Ramsey, D.P. Wolfer, V. Cestari, C. Rossi Arnaud, S.G.N. Grant, P.F. Chapman, H.P. Lipp, E. Sturani, R. Klein
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