Data di Pubblicazione:
2004
Citazione:
Structure-function relationships in the growing hexa-coordinate hemoglobin sub-family / D. de Sanctis, A. Pesce, M. Nardini, M. Bolognesi, A. Bocedi, P. Ascenzi. - In: IUBMB LIFE. - ISSN 1521-6543. - 56:11-12(2004), pp. 643-651.
Abstract:
Hemoglobin and related heme proteins, generally referred to as
‘globins’, reversibly bind gaseous diatomic ligands (O2, NO, and
CO) to a penta-coordinate heme iron atom, the ligand filling the
sixth coordination site. Over the last decade, several new globins
have been reported to display a functionally-relevant hexacoordinate
heme iron atom, whose sixth coordination site is taken
by an endogenous protein ligand. The reversible intramolecular
hexa- to penta-coordination process at the heme-Fe atom modulates
exogenous ligand binding properties of hexa-coordinate globins.
Here, we review current knowledge on hexa-coordinate globins in
terms of their structural and functional properties.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Cytoglobin; Hemoglobin; Hexacoordinate heme; Myoglobin; Neuroglobin
Elenco autori:
D. de Sanctis, A. Pesce, M. Nardini, M. Bolognesi, A. Bocedi, P. Ascenzi
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