System for the colon delivery of drugs subject to enzyme degradation and/or poorly absorbed in the gastrointestinal tract
Brevetto
Data di Pubblicazione:
2010
Citazione:
System for the colon delivery of drugs subject to enzyme degradation and/or poorly absorbed in the gastrointestinal tract / M.E. Sangalli, M.D. Del Curto, A. Gazzaniga, A. Maroni, L. Palugan, L. Zema, M. Spreafico.
Abstract:
Said invention refers to a pharmaceutical form for selective colon delivery of drugs or bioactive molecules degraded and/or poorly absorbed in the gastrointestinal tract. The system comprises a core consisting of the active ingredient, and a protease inhibitor layer and/or an absorption enhancer layer, said core being separated from these layers by means of a polymer that swells and/or dissolves and/or is degraded when in contact with the biological fluids present in the gastro-intestinal tract; depending on the thickness of the polymeric layer, the release of the drug can be modulated with respect to the inhibitor and/or promoter.
Tipologia IRIS:
09 - Brevetto, privativa o norma
Elenco autori:
M.E. Sangalli, M.D. Del Curto, A. Gazzaniga, A. Maroni, L. Palugan, L. Zema, M. Spreafico
Link alla scheda completa: