Data di Pubblicazione:
2010
Citazione:
SoxF genes : Key players in the development of the cardio-vascular system / M. Francois, P. Koopman, M.D. Beltrame. - In: THE INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. - ISSN 1357-2725. - 42:3(2010), pp. 445-448.
Abstract:
SoxF genes (Sox7, Sox17 and Sox18) encode a group of transcription factors that have a pivotal role in
cardio-vascular development. SOXF factors orchestrate endothelial cell fate or direct cell differentiation
in developing heart, blood vessels and lymphatic vessels. Their roles are highly conserved throughout
animal evolution. SOXF activity is finely tuned with a variety of cell type-specific co-factors and partner
proteins to effect transcription of genes critical for endothelial cell phenotype and function. Because SOXF
factors play a central role in cardiogenesis, vasculogenesis and lymphangiogenesis, SOXF gene mutations
figure prominently in the aetiology of human vascular disease.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Sox ; Transcription ; Development ; Cardio-vascular system ; Genetics
Elenco autori:
M. Francois, P. Koopman, M.D. Beltrame
Link alla scheda completa: