Data di Pubblicazione:
2007
Citazione:
Developmental expression of tryptophan hydroxylase gene in Ciona intestinalis / R. Pennati, S. Candiani, M. Biggiogero, G. Zega, S. Groppelli, D. Oliveri, M. Parodi, F. De Bernardi, M. Pestarino. - In: DEVELOPMENT GENES AND EVOLUTION. - ISSN 0949-944X. - 217:4(2007), pp. 307-313.
Abstract:
In order to describe the serotonergic system in a tunicate larva, we cloned a gene encoding for tryptophan hydroxylase (TPH), the rate-limiting enzyme in serotonin synthesis, in the ascidian Ciona intestinalis and studied its expression pattern during development. Ci-TPH expression was found from tailbud stage in the precursor cells of the visceral ganglion and in the tail. In the larva TPH-expressing neurons formed two clusters in the anterior central nervous system, at the level of the visceral ganglion. Moreover we found Ci-TPH expression at the level of muscle cells of the tail and suggested that this localization might be at the level of neuro-muscolar junctions. Moreover we discussed the involvement of serotonin in the control of larval locomotory activity.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
serotonin, ascidian ; nervous system ; tryptophan hydroxylase (TPH) ; Ciona intestinalis
Elenco autori:
R. Pennati, S. Candiani, M. Biggiogero, G. Zega, S. Groppelli, D. Oliveri, M. Parodi, F. De Bernardi, M. Pestarino
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