Environmental Enrichment and Fluoxetine Neurogenic Stimuli Increase ß3-Tubulin Immature Neurons in Meninges Through Trkb-Mediated Signaling
Articolo
Data di Pubblicazione:
2021
Citazione:
Environmental Enrichment and Fluoxetine Neurogenic Stimuli Increase ß3-Tubulin Immature Neurons in Meninges Through Trkb-Mediated Signaling / S. Zorzin, A. Corsi, A. Pino, A. Amenta, G. Francesco Fumagalli, C. Chiamulera, F. Bifari, I. Decimo. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1661-6596. - 22:19(2021), pp. 657.1-657.22. [10.3390/ijms221910657]
Abstract:
Neural precursors (NPs) present in the hippocampus can be modulated by several neuro-
genic stimuli, including environmental enrichment (EE) acting through BDNF-TrkB signaling. We
have recently identified NPs in meninges; however, the meningeal niche response to pro-neurogenic
stimuli has never been investigated. To this aim, we analyzed the effects of EE exposure on NP
distribution in mouse brain meninges. Following neurogenic stimuli, although we did not detect
modification of the meningeal cell number and proliferation, we observed an increased number of
neural precursors in the meninges. A lineage tracing experiment suggested that EE-induced β3-
Tubulin+ immature neuronal cells present in the meninges originated, at least in part, from GLAST+
radial glia cells. To investigate the molecular mechanism responsible for meningeal reaction to EE
exposure, we studied the BDNF-TrkB interaction. Treatment with ANA-12, a TrkB non-competitive
inhibitor, abolished the EE-induced meningeal niche changes. Overall, these data showed, for the
first time, that EE exposure induced meningeal niche remodeling through TrkB-mediated signaling.
Fluoxetine treatment further confirmed the meningeal niche response, suggesting it may also respond
to other pharmacological neurogenic stimuli. A better understanding of the neurogenic stimuli
modulation for meninges may be useful to improve the effectiveness of neurodegenerative and
neuropsychiatric treatments.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
neurogenesis; TrkB; BDNF; meninges; ANA-12; meningeal niche; radial glia cell; neural precursor; enriched environment; EE; ENR
Elenco autori:
S. Zorzin, A. Corsi, A. Pino, A. Amenta, G. Francesco Fumagalli, C. Chiamulera, F. Bifari, I. Decimo
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