Data di Pubblicazione:
2022
Citazione:
Key players in progesterone and testosterone action: the metabolizing enzymes / S. Giatti, S. Diviccaro, R.C. Melcangi. - In: CURRENT OPINION IN ENDOCRINE AND METABOLIC RESEARCH. - ISSN 2451-9650. - 23:(2022 Apr), pp. 100319.1-100319.8. [10.1016/j.coemr.2022.100319]
Abstract:
Neuroactive steroids are crucial regulators of nervous functions. In the brain, progesterone, testosterone, and their metabolites exert their functions through complex regulation. In particular, the metabolism of these steroids and their subsequent interaction with different receptors orchestrate the fine-tuning of neuronal and glial functions. The key enzymes modulating progesterone and testosterone mechanism of action in the brain are here discussed.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
3-Alpha hydroxysteroid oxidoreductase; 5-Alpha reductases; 5-Beta reductases; Neuroactive steroids;
Elenco autori:
S. Giatti, S. Diviccaro, R.C. Melcangi
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