Is red distribution width a valid tool to predict impaired iron transport in heart failure?
Articolo
Data di Pubblicazione:
2023
Citazione:
Is red distribution width a valid tool to predict impaired iron transport in heart failure? / J. Campodonico, E. Carulli, F. Doni, G.L. Russo, D. Junod, M. Gaudenzi Asinelli, A. Bonomi, F. De Martino, C. Vignati, B. Pezzuto, P. Agostoni. - In: FRONTIERS IN CARDIOVASCULAR MEDICINE. - ISSN 2297-055X. - 10:(2023), pp. 1133233.1-1133233.7. [10.3389/fcvm.2023.1133233]
Abstract:
Background: Impaired iron transport (IIT) is a form of iron deficiency (ID) defined as transferrin saturation (TSAT) < 20% irrespective of serum ferritin levels. It is frequently observed in heart failure (HF) where it negatively affects prognosis irrespective of anaemia. Objectives: In this retrospective study we searched for a surrogate biomarker of IIT. Methods: We tested the predictive power of red distribution width (RDW), mean corpuscular volume (MCV) and mean corpuscular haemoglobin concentration (MCHC) to detect IIT in 797 non-anaemic HF patients. Results: At ROC analysis, RDW provided the best AUC (0.6928). An RDW cut-off value of 14.2% identified patients with IIT, with positive and negative predictive values of 48 and 80%, respectively. Comparison between the true and false negative groups showed that estimated glomerular filtration rate (eGFR) was significantly higher (p = 0.0092) in the true negative vs. false negative group. Therefore, we divided the study population according to eGFR value: 109 patients with eGFR ≥ 90 ml/min/1.73 m2, 318 patients with eGFR 60-89 ml/min/1.73 m2, 308 patients with eGFR 30-59 ml/min/1.73 m2 and 62 patients with eGFR < 30 ml/min/1.73 m2. In the first group, positive and negative predictive values were 48 and 81% respectively, 51 and 85% in the second group, 48 and 73% in the third group and 43 and 67% in the fourth group. Conclusion: RDW may be seen as a reliable marker to exclude IIT in non-anaemic HF patients with eGFR ≥60 ml/min/1.73 m2.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
heart failure; iron deficiency; iron metablism disorder; iron metabolism; red cell distribution width (RDW)
Elenco autori:
J. Campodonico, E. Carulli, F. Doni, G.L. Russo, D. Junod, M. Gaudenzi Asinelli, A. Bonomi, F. De Martino, C. Vignati, B. Pezzuto, P. Agostoni
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