Data di Pubblicazione:
2023
Citazione:
Attributable Fraction of Cancer Related to Occupational Exposure in Italy / G. Collatuzzo, F. Turati, M. Malvezzi, E. Negri, C. La Vecchia, P. Boffetta. - In: CANCERS. - ISSN 2072-6694. - 15:8(2023 Apr 10), pp. 2234.1-2234.16. [Epub ahead of print] [10.3390/cancers15082234]
Abstract:
Background: Exposure to occupational carcinogens is an important and avoidable cause of
cancer. We aimed to provide an evidence-based estimate of the burden of occupation-related cancers
in Italy. Methods: The attributable fraction (AF) was calculated based on the counterfactual scenario
of no occupational exposure to carcinogens. We included exposures classified as IARC group 1 and
with reliable evidence of exposure in Italy. Relative risk estimates for selected cancers and prevalences
of exposure were derived from large-scale studies. Except for mesothelioma, a 15–20-year latency
period between exposure and cancer was considered. The data on cancer incidence in 2020 and
mortality in 2017 in Italy were obtained from the Italian Association of Cancer Registries. Results:
The most prevalent exposures were UV radiation (5.8%), diesel exhaust (4.3%), wood dust (2.3%) and
silica dust (2.1%). Mesothelioma had the largest AF to occupational carcinogens (86.6%), followed by
sinonasal cancer (11.8%) and lung cancer (3.8%). We estimated that 0.9% of cancer cases (N~3500) and
1.6% of cancer deaths (N~2800) were attributable to occupational carcinogens in Italy. Of these, about
60% were attributable to asbestos, 17.5% to diesel exhaust, followed by chromium and silica dust (7%
and 5%). Conclusions: Our estimates provide up-to-date quantification of the low, but persistent,
burden of occupational cancers in Italy.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
cancer; occupation; occupational carcinogens; occupational exposure; attributable fraction; epidemiology
Elenco autori:
G. Collatuzzo, F. Turati, M. Malvezzi, E. Negri, C. La Vecchia, P. Boffetta
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