Synaptic Proteins as Fluid Biomarkers in Alzheimer's Disease: A Systematic Review and Meta-Analysis
Articolo
Data di Pubblicazione:
2022
Citazione:
Synaptic Proteins as Fluid Biomarkers in Alzheimer's Disease: A Systematic Review and Meta-Analysis / F. Roveta, A. Cermelli, S. Boschi, F. Ferrandes, A. Grassini, A. Marcinnò, M. Spina, E. Rubino, T. Borsello, A. Vercelli, I. Rainero. - In: JOURNAL OF ALZHEIMER'S DISEASE. - ISSN 1387-2877. - 90:4(2022), pp. 1381-1393. [10.3233/JAD-220515]
Abstract:
Background: Synaptic disruption precedes neuronal death and correlates with clinical features of Alzheimer's disease (AD). The identification of fluid biomarkers of synaptic damage is emerging as a goal for early and accurate diagnosis of the disease.Objective: To perform a systematic review and meta-analysis to determine whether fluid biomarkers of synaptic damage are impaired in AD.Methods: PubMed, Scopus, EMBASE, and Web of Science were searched for articles reporting synaptic proteins as fluid biomarkers in AD and cognitively unimpaired (CU) individuals. Pooled effect sizes were determined using the Hedge G method with random effects. Questions adapted from the Quality Assessment of Diagnostic Accuracy Studies were applied for quality assessment. A protocol for this study has been previously registered in PROSPERO (registration number: CRD42021277487).Results: The search strategy identified 204 articles that were assessed for eligibility. A total of 23 studies were included in the systematic review and 15 were included in the meta-analysis. For Neurogranin, 827 AD and 1,237 CU subjects were included in the meta-analysis, showing a significant increase in cerebrospinal fluid of patients with AD compared to CU individuals, with an effect size of 1.01 (p < 0.001). A significant increase in SNAP-25 and GAP-43 levels in CSF of patients with AD was observed.Conclusion: Neurogranin, SNAP-25, and GAP-43 are possible biomarkers of synaptic damage in AD, and other potential synaptic biomarkers are emerging. This meta-analysis also revealed that there are still relatively few studies investigating these biomarkers in patients with AD or other dementias and showed wide heterogeneity in literature.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Alzheimer’s disease; GAP-43; SNAP-25; blood; cerebrospinal fluid; meta-analysis; neurogranin; synaptic dysfunction; synaptotagmin-1; systematic review
Elenco autori:
F. Roveta, A. Cermelli, S. Boschi, F. Ferrandes, A. Grassini, A. Marcinnò, M. Spina, E. Rubino, T. Borsello, A. Vercelli, I. Rainero
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