Twelve Weeks of Intermittent Caloric Restriction Diet Mitigates Neuroinflammation in Midlife Individuals with Multiple Sclerosis: A Pilot Study with Implications for Prevention of Alzheimer's Disease
Articolo
Data di Pubblicazione:
2023
Citazione:
Twelve Weeks of Intermittent Caloric Restriction Diet Mitigates Neuroinflammation in Midlife Individuals with Multiple Sclerosis: A Pilot Study with Implications for Prevention of Alzheimer's Disease / F. Rahmani, L. Ghezzi, V. Tosti, J. Liu, S. Song, A.T. Wu, J. Rajamanickam, K.A. Obert, T.L.S. Benzinger, B. Mittendorfer, L. Piccio, C.A. Raji. - In: JOURNAL OF ALZHEIMER'S DISEASE. - ISSN 1387-2877. - (2023), pp. 1-11. [Epub ahead of print] [10.3233/JAD-221007]
Abstract:
Background: Multiple sclerosis (MS) is a prototype neuroinflammatory disorder with increasingly recognized role for neurodegeneration. Most first-line treatments cannot prevent the progression of neurodegeneration and the resultant disability. Interventions can improve symptoms of MS and might provide insights into the underlying pathology. Objective: To investigate the effect of intermittent caloric restriction on neuroimaging markers of MS. Methods: We randomized ten participants with relapsing remitting MS to either a 12-week intermittent calorie restriction (iCR) diet (n = 5) or control (n = 5). Cortical thickness and volumes were measured through FreeSurfer, cortical perfusion was measured by arterial spin labeling and neuroinflammation through diffusion basis spectrum imaging. Results: After 12 weeks of iCR, brain volume increased in the left superior and inferior parietal gyri (p: 0.050 and 0.049, respectively) and the banks of the superior temporal sulcus (p: 0.01). Similarly in the iCR group, cortical thickness improved in the bilateral medial orbitofrontal gyri (p: 0.04 and 0.05 in right and left, respectively), the left superior temporal gyrus (p: 0.03), and the frontal pole (p: 0.008) among others. Cerebral perfusion decreased in the bilateral fusiform gyri (p: 0.047 and 0.02 in right and left, respectively) and increased in the bilateral deep anterior white matter (p: 0.03 and 0.013 in right and left, respectively). Neuroinflammation, demonstrated through hindered and restricted water fractions (HF and RF), decreased in the left optic tract (HF p: 0.02), and the right extreme capsule (RF p: 0.007 and HF p: 0.003). Conclusion: These pilot data suggest therapeutic effects of iCR in improving cortical volume and thickness and mitigating neuroinflammation in midlife adults with MS.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Alzheimer’s disease; arterial spin labeling; caloric restriction; diffusion basis spectrum imaging; multiple sclerosis; neuroinflammation; prevention; relative cerebral blood flow;
Elenco autori:
F. Rahmani, L. Ghezzi, V. Tosti, J. Liu, S. Song, A.T. Wu, J. Rajamanickam, K.A. Obert, T.L.S. Benzinger, B. Mittendorfer, L. Piccio, C.A. Raji
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