Data di Pubblicazione:
2023
Citazione:
Impact of Sacubitril/Valsartan on Circulating microRNA in Patients with Heart Failure / M. Brioschi, Y. D’Alessandra, M. Mapelli, I. Mattavelli, E. Salvioni, S. Eligini, A. Mallia, V. Ricci, E. Gianazza, S. Ghilardi, P. Agostoni, C. Banfi. - In: BIOMEDICINES. - ISSN 2227-9059. - 11:4(2023), pp. 1037.1-1037.14. [10.3390/biomedicines11041037]
Abstract:
Sacubitril/Valsartan, used for the treatment of heart failure (HF), is a combination of two
drugs, an angiotensin receptor inhibitor, and a neprilysin inhibitor, which activates vasoactive pep-
tides. Even though its beneficial effects on cardiac functions have been demonstrated, the mechanisms
underpinning these effects remain poorly understood. To achieve more mechanistic insights, we
analyzed the profiles of circulating miRNAs in plasma from patients with stable HF with reduced
ejection function (HFrEF) and treated with Sacubitril/Valsartan for six months. miRNAs are short
(22–24 nt) non-coding RNAs, which are not only emerging as sensitive and stable biomarkers for
various diseases but also participate in the regulation of several biological processes. We found that
in patients with high levels of miRNAs, specifically miR-29b-3p, miR-221-3p, and miR-503-5p, Sacu-
bitril/Valsartan significantly reduced their levels at follow-up. We also found a significant negative
correlation of miR-29b-3p, miR-221-3p, and miR-503-5p with VO2 at peak exercise, whose levels
decrease with HF severity. Furthermore, from a functional point of view, miR-29b-3p, miR-221-3p,
and miR-503-5p all target Phosphoinositide-3-Kinase Regulatory Subunit 1, which encodes regulatory
subunit 1 of phosphoinositide-3-kinase. Our findings support that an additional mechanism through
which Sacubitril/Valsartan exerts its functions is the modulation of miRNAs with potentially relevant
roles in HFrEF pathophysiology.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Sacubitril/Valsartan; heart failure; miRNA
Elenco autori:
M. Brioschi, Y. D’Alessandra, M. Mapelli, I. Mattavelli, E. Salvioni, S. Eligini, A. Mallia, V. Ricci, E. Gianazza, S. Ghilardi, P. Agostoni, C. Banfi
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