Data di Pubblicazione:
2022
Citazione:
Terbium radionuclides production by deuteron beams irradiation for medical applications / S. Carminati, M. Colucci, F. Haddad, G. Flavia, S. Manenti - In: 6-th INCC2022 - Programme and Abstract BookLanzhou, Gansu Province, P. R. China : Lanzhou University, 2022. - pp. 57-58 (( Intervento presentato al 6. convegno International Nuclear Chemistry Congress tenutosi a Lanzhou nel 2022.
Abstract:
The uniqueness in the terbium family consists in the fact that it has four radioisotopes of interest from a medical point of view: Tb-155 (half-life = 5.32 d) and Tb-152 (half-life = 17.5 h) can be used for SPECT and PET respectively; the properties of Tb-161 (half-life = 6.89 d) make it interesting from a therapeutic point of view because it allows a combined therapy with beta- and Auger electrons which has proved to be very effective in preclinical studies; finally, Tb-149 (half- life = 4.1 h) can be proposed for metabolic radiotherapy with alpha particles, therefore of interest for small metastases, with the associated possibility of diagnostics with PET due to the associated β+ emission [1].
New measurements and data set for the natDy(d,x)149,152,155,161Tb nuclear reaction are needed due to the lack of experimental data in literature. The stacked-foil activation technique irradiating at different energies thin natural Dy targets by deuteron beams was used to experimentally determine the excitation functions of the terbium isotopes and contaminants in the energy range between 15 MeV and 32 MeV. The irradiations were carried out at the ARRONAX Cyclotron Center, Nantes, France (Ed up to 35 MeV and 750 μA intensity) with a
constant current of about 150 nA for a duration of 1 h. The irradiated targets were analyzed at LASA Laboratory in Milano.
We present preliminary results of the activation cross-sections of
deuteron induced nuclear reactions for natDy(d,x)155,161Tb production and of the other co-produced contaminants, and we compare them with the other data sets presented in literature and with the results of simulation with EMPIRE 3.2.2 and TALYS codes.
Tipologia IRIS:
03 - Contributo in volume
Keywords:
Terbium; dysprosium; PET; SPECT; Metabolic Radiotherapy; theranostics applications; cyclotron; deuterons
Elenco autori:
S. Carminati, M. Colucci, F. Haddad, G. Flavia, S. Manenti
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Titolo del libro:
6-th INCC2022 - Programme and Abstract Book