Data di Pubblicazione:
2023
Citazione:
T follicular helper phenotype mycosis fungoides associated with acanthosis nigricans / C.B. Spigariolo, E. Berti, A. Cerri, L. Venegoni, G. Croci, S.A. Violetti. - In: JOURNAL OF CUTANEOUS PATHOLOGY. - ISSN 0303-6987. - 50:5(2023 May), pp. 420-424. [10.1111/cup.14405]
Abstract:
The association between acanthosis nigricans (AN) and mycosis fungoides (MF) has rarely been described, but it is known that MF may appear as AN-like vegetating and papillomatous plaques in skin folds, or may be associated with paraneoplastic AN. There have also been recent descriptions of a form of "intertriginous MF" that is characterized by skin fold involvement and the expression of T follicular helper (TFH) markers, and that often has an aggressive course. We describe the case of a 48-year-old man affected by MF associated with AN, whose lesions were characterized by a TFH immunophenotype and the expression of the GATA-3 nuclear master regulator that may be related to a TFH-2 subpopulation or possible disease progression.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
GATA-3; T follicular helper; acanthosis nigricans; mycosis fungoides
Elenco autori:
C.B. Spigariolo, E. Berti, A. Cerri, L. Venegoni, G. Croci, S.A. Violetti
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