Excitation functions and yields for Re-186g production by proton and deuteron cyclotron irradiation
Poster
Data di Pubblicazione:
2008
Citazione:
Excitation functions and yields for Re-186g production by proton and deuteron cyclotron irradiation / K. Abbas, U. Holzwarth, N. Gibson, F. Simonelli, M. Bonardi, F. Groppi, S. Manenti, E. Persico. - In: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. - ISSN 1619-7070. - 35:Suppl. 2(2008 Oct), pp. S324-S324. ((Intervento presentato al convegno EANM : Annual congress of the european association of nuclear medicine tenutosi a Munich, Germany nel 2008.
Abstract:
The 186gRe is a beta-gamma emitter that, thanks to its suitable nuclear properties (t1/2 = 90.64 h, Emax-beta 1.07, 0.93 MeV, main E-gamma 137 keV), is presently used in palliation metabolic radiotherapy, with optimal perspectives for applications in radioimmunotherapy (RIT) too. In particular the energy range of the beta particles suggests that this radionuclide is a good candidate for cancers with small dimensions (from few mm to a few cm in soft tissue). The possibility to use this radionuclide for therapeutic purposes is strictly related to the possibility of increasing its specific activity (AS). This improvement is reached by substituting the common 185Re(n,gamma) production route in thermal nuclear reactor with the 186W(p,n) and/or (d,2n) cyclotron production ones, due to the possibility of radiochemical separation of the product from the target in no-carrier-added form, reaching a AS(NCA) value close to the theoretical carrier-free one AS(CF) = 6.88 GBq.microg-1.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
radionuclide production ; 186g-Re ; high specific activity ; cyclotron ; radiochemical separation ; metabolic radiotherapy ; radioimmunotherapy ; nuclear medicine
Elenco autori:
K. Abbas, U. Holzwarth, N. Gibson, F. Simonelli, M. Bonardi, F. Groppi, S. Manenti, E. Persico
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