Immune effects and exposure to ethylenebisdithiocarbamate pesticides in re-entry workers in the Netherlands
Articolo
Data di Pubblicazione:
2008
Citazione:
Immune effects and exposure to ethylenebisdithiocarbamate pesticides in re-entry workers in the Netherlands / L. van Amelsvoort, D. Mohren, J. Slangen, G. Swaen, E. Corsini, S. Fustinoni, T. Vergieva, C. Bosetti, J. Liesivuori, M. Tarkowski, C. Colosio, H. van Loveren. - In: HUMAN & EXPERIMENTAL TOXICOLOGY. - ISSN 0960-3271. - 27:9(2008 Sep), pp. 693-699.
Abstract:
Ethylenebisdithiocarbamates are widely used as fungicides in agriculture.
Although EBDC's have a low acute toxicity, they are suspected to have immune
effects at low doses. However, little human studies on these effects have been
published. In the Netherlands, a study was conducted among pesticide exposed
workers aimed at evaluating the short-term and long-term immune effects of
exposure and the relation between ethylenebisdithiocarbamate and immune effects.
Forty-one re-entry workers and 40 nonexposed controls were medically examined;
furthermore, immune parameters were determined in blood, and all participants
filled in a questionnaire regarding exposure and outcome parameters. The level of
ethylenethiourea in urine was determined as indicator of exposure. No relevant
adverse immune effects were found in the pesticide exposed workers compared with
the nonexposed controls. Also no exposure response relationship between immune
effects and ethylenebisdithiocarbamate in urine was found. This finding might be
due to very low exposure levels of the re-entry work but might also be due to a
lack of immunotoxicity of ethylenebisdithiocarbamate at normal exposure levels.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Epidemiology; Immune effects; Occupational exposure; Pesticides
Elenco autori:
L. van Amelsvoort, D. Mohren, J. Slangen, G. Swaen, E. Corsini, S. Fustinoni, T. Vergieva, C. Bosetti, J. Liesivuori, M. Tarkowski, C. Colosio, H. van Loveren
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