Data di Pubblicazione:
2021
Citazione:
Anderson-fabry disease: role of traditional and new cardiac MRI techniques / G. Caredda, P.P. Bassareo, M.V. Cherchi, G. Pontone, J.S. Suri, L. Saba. - In: BRITISH JOURNAL OF RADIOLOGY. - ISSN 0007-1285. - 94:1124(2021 Aug 01), pp. 20210020.1-20210020.11. [10.1259/bjr.20210020]
Abstract:
Anderson-Fabry (FD) disease is a rare X-linked disorder caused by different mutations in the Galactosidase a (GLA) gene, which leads to a-galactosidase A enzyme deficiency and the storage of glycosphingolipids in different kinds of organs, included the heart. This results in myocardial inflammation and left ventricular hypertrophy (LVH) and fibrosis. Echocardiography and cardiac magnetic resonance (C-MRI), in particular with new techniques, such as mapping analysis, late gadolinium enhancement (LGE) assessment and strain imaging, are important tools that allow a correct diagnosis, discriminating FD from other hypertrophic heart conditions. C-MRI is able to detect tissue alterations in the early stages of the disease, when an appropriate treatment could be more effective, and it has a fundamental role in monitoring therapy.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
G. Caredda, P.P. Bassareo, M.V. Cherchi, G. Pontone, J.S. Suri, L. Saba
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