Data di Pubblicazione:
2023
Citazione:
Maytansinol Functionalization: Towards Useful Probes for Studying Microtubule Dynamics / Z. Boiarska, H. Pérez-Peña, A. Abel, P. Marzullo, B. Álvarez-Bernad, F. Bonato, B. Santini, D. Horvath, D. Lucena-Agell, F. Vasile, M. Sironi, J.F. Díaz, A.E. Prota, S. Pieraccini, D. Passarella. - In: CHEMISTRY-A EUROPEAN JOURNAL. - ISSN 0947-6539. - 29:5(2023 Jan 24), pp. 1-12. [10.1002/chem.202203431]
Abstract:
Maytansinoids are a successful class of natural and semisynthetic tubulin binders, known for their potent cytotoxic activity. Their wider application as cytotoxins and chemical probes to study tubulin dynamics has been held back by the complexity of natural product chemistry. Here we report the synthesis of long-chain derivatives and maytansinoid conjugates. We confirmed that bulky substituents do not impact their high activity or the scaffold's binding mode. These encouraging results open new avenues for the design of new maytansine-based probes.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
chemical probes; maytansinoids; maytansinol functionalization; microtubules; tubulin
Elenco autori:
Z. Boiarska, H. Pérez-Peña, A. Abel, P. Marzullo, B. Álvarez-Bernad, F. Bonato, B. Santini, D. Horvath, D. Lucena-Agell, F. Vasile, M. Sironi, J.F. Díaz, A.E. Prota, S. Pieraccini, D. Passarella
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