Disseminated superficial actinic porokeratosis following hydroxyurea treatment: A case report
Articolo
Data di Pubblicazione:
2023
Citazione:
Disseminated superficial actinic porokeratosis following hydroxyurea treatment: A case report / M. Romagnuolo, D. Riva, S. Alberti Violetti, A. Di Benedetto, F. Barberi, C. Moltrasio. - In: AUSTRALASIAN JOURNAL OF DERMATOLOGY. - ISSN 0004-8380. - 64:1(2023 Feb), pp. E72-E75. [10.1111/ajd.13943]
Abstract:
Porokeratosis encompass a group of acquired and familial, preneoplastic, keratinization disorders, clinically characterized by atrophic macules or patches with a peripheral keratotic rim, the cornoid lamella. Genetic background is recognized as crucial in its pathophysiology, while immunosuppression and ultraviolet radiation represent triggering factors. We report the case of a woman who developed disseminate superficial actinic porokeratosis following the intake of hydroxyurea for a polycythaemia vera. Clinical, dermoscopic and histopathology data are showed, and the role of drug as a second-hit mutation trigger is discussed.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Porokeratosis; adverse effect; genetic analysis; hydroxyurea; squamous cells neoplasm mevalonate kinase deficiency
Elenco autori:
M. Romagnuolo, D. Riva, S. Alberti Violetti, A. Di Benedetto, F. Barberi, C. Moltrasio
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