SARS-CoV-2 viral entry and replication is impaired in Cystic Fibrosis airways due to ACE2 downregulation
Articolo
Data di Pubblicazione:
2023
Citazione:
SARS-CoV-2 viral entry and replication is impaired in Cystic Fibrosis airways due to ACE2 downregulation / V. Bezzerri, V. Gentili, M. Api, A. Finotti, C. Papi, A. Tamanini, C. Boni, E. Baldisseri, D. Olioso, M. Duca, E. Tedesco, S. Leo, M. Borgatti, S. Volpi, P. Pinton, G. Cabrini, R. Gambari, F. Blasi, G. Lippi, A. Rimessi, R. Rizzo, M. Cipolli. - In: NATURE COMMUNICATIONS. - ISSN 2041-1723. - 14:1(2023), pp. 132.1-132.15. [10.1038/s41467-023-35862-0]
Abstract:
As an inherited disorder characterized by severe pulmonary disease, cystic
fibrosis could be considered a comorbidity for coronavirus disease 2019.
Instead, current clinical evidence seems to be heading in the opposite direc-
tion. To clarify whether host factors expressed by the Cystic Fibrosis epithelia
may influence coronavirus disease 2019 progression, here we describe the
expression of SARS-CoV-2 receptors in primary airway epithelial cells. We show
that angiotensin converting enzyme 2 (ACE2) expression and localization are
regulated by Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)
channel. Consistently, our results indicate that dysfunctional CFTR channels
alter susceptibility to SARS-CoV-2 infection, resulting in reduced viral entry
and replication in Cystic Fibrosis cells. Depending on the pattern of ACE2
expression, the SARS-CoV-2 spike (S) protein induced high levels of Interleukin
6 in healthy donor-derived primary airway epithelial cells, but a very weak
response in primary Cystic Fibrosis cells. Collectively, these data support that
Cystic Fibrosis condition may be at least partially protecting from SARS-CoV-2
infection.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
V. Bezzerri, V. Gentili, M. Api, A. Finotti, C. Papi, A. Tamanini, C. Boni, E. Baldisseri, D. Olioso, M. Duca, E. Tedesco, S. Leo, M. Borgatti, S. Volpi, P. Pinton, G. Cabrini, R. Gambari, F. Blasi, G. Lippi, A. Rimessi, R. Rizzo, M. Cipolli
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