Clinical features of an adult-onset Leigh syndrome caused by the T9176C mutation in the mitochondrial DNA ATPase 6 gene
Articolo
Data di Pubblicazione:
2008
Citazione:
Clinical features of an adult-onset Leigh syndrome caused by the T9176C mutation in the mitochondrial DNA ATPase 6 gene / D. Ronchi, A. Bordoni, R. Virgilio, E. Fassone, A. DiFonzo, M. Servida, M. Ronconi, V. Lucchini, M. Matteoli, N. Bresolin, G.P. Comi. - In: JOURNAL OF NEUROLOGY. - ISSN 0340-5354. - 255:Suppl. 2(2008 Jun), pp. 66-66. ((Intervento presentato al 18. convegno Meeting of the European Neurological Society tenutosi a Nice nel 2008.
Abstract:
Several lines of evidence support early immunomodulatory treatment of relapsing multiple sclerosis with either recombinant beta-interferons or glatiramer acetate and positive results from phase III trials encourage start of treatment even in patients with clinical isolated syndrome (CIS). However, currently available drugs for basic therapy are only partially effective and patients may still encounter relapses or disease progression. As treatment-refractory, clinically active MS can quickly lead to irreversible neurological disability there is an urgent need for more effective therapeutic strategies. The major goal is to reduce the damage, protect the tissue and enhance repair. In order to achieve these goals we not only need effective and safe drugs but also the appropriate study designs to really detect the most relevant outcomes 2, 7.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Clinical trial design; Multiple sclerosis; Outcomes; Repair
Elenco autori:
D. Ronchi, A. Bordoni, R. Virgilio, E. Fassone, A. DiFonzo, M. Servida, M. Ronconi, V. Lucchini, M. Matteoli, N. Bresolin, G.P. Comi
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