Incidence and status of insulin secretion in pregnant women with flat plasma glucose profiles during oral glucose tolerance test
Articolo
Data di Pubblicazione:
2022
Citazione:
Incidence and status of insulin secretion in pregnant women with flat plasma glucose profiles during oral glucose tolerance test / D. Szoke, C. Robbiano, R. Dolcini, L. Montefusco, G. Barbara Aiello, S. Caruso, A. Ottolenghi, S. Birindelli, M. Panteghini. - In: CLINICAL BIOCHEMISTRY. - ISSN 0009-9120. - 109 -110:(2022 Nov), pp. 23-27. [10.1016/j.clinbiochem.2022.08.010]
Abstract:
Objectives: Flat shaped glucose curves (FC) during oral glucose tolerance test (OGTT) in pregnant women (PW) are a not uncommon finding. We aimed to define the FC incidence in a large PW cohort and to describe the status of insulin and C-peptide secretion in women with FC when compared with a well-matched control group.
Methods: 1050 PW performing OGTT for gestational diabetes screening were enrolled. An increase <6 % in
plasma glucose (PG) during OGTT defined a FC. Serum samples for measuring insulin and C-peptide were also obtained.
Results: 61 (5.8 %) women showed a FC. 60 of them, paired to a group of 60 no-FC women matched for age, body mass index and gestational age, were further investigated. C-peptide and insulin concentrations were significantly lower (P < 0.001) in FC in both 1-h and 2-h OGTT samples. When incremental area under the curves (AUC) normalized to PG were estimated, only AUCinsulin remained however significantly lower. The insulin sensitivity index was higher in FC.
Conclusions: PW with FC showed a hypersensitivity to insulin with normal β-cell function. Moreover, a delayed
glucose absorption could be hypothesised because of the slight but continuously increasing shape of insulin curve
found in FC group. Both phenomena could occur in parallel and contribute to FC.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
oral glucose tolerance test; pregnancy; flat glucose curve; insulin secretion; β-Cell function
Elenco autori:
D. Szoke, C. Robbiano, R. Dolcini, L. Montefusco, G. Barbara Aiello, S. Caruso, A. Ottolenghi, S. Birindelli, M. Panteghini
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