Fluorescence in situ hybridization dissection of a chronic myeloid leukemia case bearing the apparently balanced translocations (9;22)(q34;q11.2) and (11;11)(p15;q13)
Articolo
Data di Pubblicazione:
2009
Citazione:
Fluorescence in situ hybridization dissection of a chronic myeloid leukemia case bearing the apparently balanced translocations (9;22)(q34;q11.2) and (11;11)(p15;q13) / F. Malvestiti, D. Colombo, D. Perego, O. Rodeschini, P. Finelli, L. Larizza, D. Giardino. - In: CANCER GENETICS AND CYTOGENETICS. - ISSN 0165-4608. - 188:1(2009 Jan), pp. 42-47.
Abstract:
We report on a patient with chronic myeloid leukemia (CML), which was detected by conventional cytogenetic analysis, to carry two different acquired and apparently balanced translocations, (9;22)(q34;q11.2) and (11;11)(p15;q13). By fluorescence in situ hybridization characterization, we were able to finely map the genomic regions involved in the translocation breakpoints and to disclose concomitant deletions adjacent to the breakpoints on the two derivative chromosomes 11 and the derivative chromosome 22, and the insertion of a segment from chromosome band 11q12.2 into the derivative chromosome 9. We discuss the putative mechanism that could have led to the formation of this complex rearrangement and speculate on the role in leukemogenesis played by the genes mapping at the breakpoints and within the deleted regions.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
chronic myeloid leukemia ; fluorescence in situ hybridization ; complex chromosome rearrangement
Elenco autori:
F. Malvestiti, D. Colombo, D. Perego, O. Rodeschini, P. Finelli, L. Larizza, D. Giardino
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