Gli idrocarburi policiclici aromatici urinari nel monitoraggio biologico delle esposizioni a basse dosi nel settore dell’edilizia
Articolo
Data di Pubblicazione:
2008
Citazione:
Gli idrocarburi policiclici aromatici urinari nel monitoraggio biologico delle esposizioni a basse dosi nel settore dell’edilizia / L. Campo, P.E. Cirla, I. Martinotti, S. Facchinetti, T. Storto, P. Leghissa, V. Foà, S. Fustinoni. - In: GIORNALE ITALIANO DI MEDICINA DEL LAVORO ED ERGONOMIA. - ISSN 1592-7830. - 30:3, suppl 2(2008), pp. 112-113. (Intervento presentato al 71. convegno Congresso Nazionale SIMLII tenutosi a Palermo nel 2008).
Abstract:
Aim of this work was to investigate the use of unmetabolized polycyclic aromatic hydrocarbons in urine (U-PAHs) as
possible biomarker of exposure.
Forty roofers (12 non smokers, 28 smokers) participated to the study and for each workers three urine samples were obtained: on Monday morning (baseline, BL), at the beginning (BS) and at end (ES) of the work
shift. Quantification of 13 U-PAHs was performed via GC/MS. 1-Hydroxypyrene was also quantified.
Urinary naphthalene and phenanthrene were the most abundant analytes. Their median levels were 155, 173, 210 ng/L and 24, 34, 36
ng/L (BL, BS and ES samples). Significant differences were found comparing BL/ES and BS/ES samples. High molecular-weight
compounds (from chrysene to benzo[a]pyrene) were always below the quantification limit. Naphthalene levels were higher than in asphalt and construction workers previously investigated. 1-Hydroxypyrene levels
(300, 412, 500 μg/L) were similar to those found in asphalt workers. A strong influence of cigarette smoking was evidenced on 1-hydroxypyrene but not on naphthalene excretion.
In conclusion, the determination of U-PAHs permitted to deeper characterize roofer’s occupational exposure. U-PAHs, and U-NAP in
particular, showed to be more specific than 1-hydroxypyrene and may be used as sensitive biomarker of exposure.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
L. Campo, P.E. Cirla, I. Martinotti, S. Facchinetti, T. Storto, P. Leghissa, V. Foà, S. Fustinoni
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