Data di Pubblicazione:
1999
Citazione:
Pelvic and Paraortic Lymph Nodal Status in Advanced
Ovarian Cancer and Survival / F. Parazzini, G. Valsecchi, G. Bolis, P. Guarnerio, S. Reina, G. Polverino, D. Silvestri. - In: GYNECOLOGIC ONCOLOGY. - ISSN 0090-8258. - 74:1(1999 Jul), pp. 7-11. [10.1006/gyno.1999.5397]
Abstract:
Background. In order to analyze the prognostic role of node
involvement in advanced ovarian cancer, we have analyzed data
from a randomized clinical trial on advanced ovarian cancer.
Methods. Cases were 456 women who entered a randomized
multicentric clinical trial comparing two cisplatin-based schemes
of treatment after cytoreductive surgery for advanced stage III–IV
ovarian cancer. They underwent selective pelvic and/or paraortic
lymphadenectomy.
Results. A total of 161 (35.3%) cases had positive nodes. The
frequency of positive nodes was statistically significantly higher in
FIGO stage IV than in stage III. Also grade 3 tumors were more
likely to have positive nodes than grade 1–2 tumors. No association
was observed between nodal status and response to chemotherapy.
The 3-year survival was 46.2 (standard error (SE) 5 3.4
based on 147 deaths) and 44.6 (SE 5 4.4, based on 84 deaths),
respectively, in negative and positive node groups. The corresponding
values, when the analysis was performed considering
only subjects with residual tumor <1 cm or absent, after first-line
cytoreductive surgery were 66.2 (SE 5 5.7) and 62.4 (SE 5 9.6).
Conclusions. We did not find any association between nodal
status and survival. Particularly, nodal status was not a prognostic
factor for survival in the subgroup of women with residual tumor
<1 cm or absent after cytoreductive surgery.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
F. Parazzini, G. Valsecchi, G. Bolis, P. Guarnerio, S. Reina, G. Polverino, D. Silvestri
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